Low Vitamin K intake
Reduced Vitamin K absorption (e.g. malabsorption)
Increased Vitamin K intake
Reduced absorption of warfarin (Cholesteramine)
Albumin binding does NOT affect
Drugs – Potentiating – listed below
Drugs counteracting – list below
Impaired coagulation – reduction in coagulation factors
Patients taking warfarin should eat a diet that is constant in vitamin K.
Minimize changes in intake of green leafy vegetables (spinach, greens, and broccoli), green peas, and oriental green tea.
Conditions that interfere with vitamin K uptake or interfere with liver function will increase the warfarin effect.
Expect a longer Prothrombin time in patients with CHF, jaundice, hepatitis, liver failure, diarrhea, or extensive cancer or connective tissue disease.
Expect a longer Prothrombin time when patients receiving warfarin are hospitalized for any reason.
Metabolic alterations can affect the Prothrombin time.
Expect a longer Prothrombin time in patients with hyperthyroidism or high fever.
shorter Prothrombin time in patients with hypothyroidism.
Vitamin E - megadoses
Toprani Advanced Lab Systems, 2005
Suflam Appt, 10 Haribhakti Colony, Racecourse, Vadodara - Guj 390007 India